Table I.

Schema for bin assignments based on relative mean normalized total dose delivered to normal lung. Starting doses for each bin are indicated by an asterisk.

Dose level (Gy per fraction)	Total Dose (Gy)	Equivalent Dose in 2Gy fractions	Bin 1 0 – 0.119	Bin 2 0.12 – 0.179	Bin 3 0.18 – 0.239	Bin 4 0.24 – 0.309	${\text{rNTD}}_{\text{mean}}=\frac{{\text{NTD}}_{\text{mean}}}{\text{Normalized PTV Dose}}$ Bin 5 0.31 – 0.41
2.28	57	60	0-11	11-12	12-15	15-22*	22-40*
2.53	63.25	70	0-11	11-13	13-16*	16-26	40-50
2.77	69.25	80	0-12	12-15	15-22	22-40	40-65
3.00	75	90	0-12	12-16*	16-26	26-50	50-80
3.22	80.5	100	0-13*	13-21	21-38	38-61	61-80+
3.42	85.5	110	10-21	15-23	26-50	High	High
3.62	90.5	120	15-23	18-26	38-61	High	High
Number of Patients			4	3	8	24	2

NTD = Normalized Total Dose in 2 Gy fractions

rNTDmean = Volume Relative NTDmean of both lungs

Shaded area ^∼ 20% pneumonitis (Grade 2 or greater) risk level 5 Pilot Phase Patients