Figure 2.

Central IGF-I does not affect central LPS-induced sickness. Social exploration, time spent investigating a novel protected juvenile mouse, was assessed as an index of sickness behavior (A). Body weight change (B) was determined over the indicated time intervals relative to LPS treatment. Feed disappearance over the same intervals (C) was used as an estimate of feed intake. Data were analyzed as repeated measures by ANOVA. n = 16 to 19 for the data in (A) and n = 11 to 13 per treatment for data in (B) and (C)