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. Author manuscript; available in PMC: 2011 Feb 28.
Published in final edited form as: Math Biosci. 2008 Sep 20;217(1):27–42. doi: 10.1016/j.mbs.2008.09.003

Figure 6.

Figure 6

Qualitative Structure of the Indirect Response Model: LPS binds to the receptor (R) and forms the complex (LPSR) while it activates the signaling complex (DR*) which indirectly stimulates the production rate Kin, P of the pro-inflammatory (P) response. The pro-inflammatory response indirectly stimulates the production rate of the energetic (E) response (Kin, E) and the production rate of anti-inflammatory (A) response (Kin, A). The energetic response will stimulate both pro-inflammation and anti-inflammation whilst anti-inflammation will serve as the immunoregulatory component of the system restoring homeostasis intracellularly.