Table 2.
Claudin-7 mRNA levels in normal and affected tissues normalised to the β-actin mRNA level.
| Variable | mRNA level in normal tissue Mean ± S.D. | Pa | mRNA level in adenomas/carcinomas Mean ± S.D. | Pa | Pb |
|---|---|---|---|---|---|
| Healthy individuals | 1.19 ± 0.70 | ||||
| Individuals with mild/moderate dysplasia | 1.24 ± 0.67 | NS | 0.84 ± 0.58 | NS | <0.001 |
| Individuals with severe dysplasia | 1.34 ± 0.75 | NS | 0.87 ± 0.69 | NS | <0.01 |
| Cancer patients | 0.82 ± 0.73 (distant) 0.83 ± 0.66 (adjacent) |
NS NS |
0.44 ± 0.48 " |
<0.001 |
<0.01 <0.001 |
NS = not significant.
a) p value for the comparison to the expression levels in tissue from healthy individuals using Kruskal Wallis and Dunn's Multiple Comparison test.
b) p value for the comparison of the expression levels in normal and affected tissue from the same individual using Paired Student's t-test.