Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2011 Mar;4(2):165–178. doi: 10.1242/dmm.004077

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2011. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

PMC Copyright notice

Fig. 3. — Second harmonic generation (SHG) imaging of collagen fibril linearization during mammary gland tumorigenesis. Images are representative of whole, unfixed mammary glands of MMTV-neu mice [which carry an activated neu oncogene driven by a mouse mammary tumor virus (MMTV) promoter] and show that collagen fibril linearity increases with malignant progression, correlating with increased tissue stiffness. Arrowheads indicate linearized collagen fibrils. Image adapted, with permission, from Levental et al. (Levental et al., 2009).