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. 2011 Mar;4(2):228–239. doi: 10.1242/dmm.006130

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© 2011. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms

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Fig. 2. — Altered levels of serum biomarkers, anemia and skin abnormalities in induced SHP-2-deficient mice. (A) Shown are the mean levels of the indicated biomarkers in serum ± 1 s.e.m. of tamoxifen-injected (at 6–8 weeks) moribund ptpn11^fl/fl ert2-cre mice and littermate control mice (n=6 each genotype). Age range of mice at the time of analysis was 9–12 weeks. ALKP and AST concentrations are shown in U/l; BUN, mg/dl; phosphorous, μg/ml; creatinine, μg/cl. Statistical significance was determined using a two sample Student’s t-test. *P<0.05; **P<0.005. (B) Depicted are mean hematocrit (percent blood volume) and reticulocyte counts (percent blood cells) ± 1 s.e.m. performed on heparinized whole blood from mice in A. Statistical significance was determined using a two sample Student’s t-test. (C) Representative H&E-stained skin section (n=6) of a tamoxifen-injected (at 6 weeks of age) moribund ptpn11^fl/fl ert2-cre mouse and a littermate ptpn11^+/+ control showing hyperkeratosis (k) and acanthosis (a) in the former. Analysis was performed 4 weeks after tamoxifen injection. Scale bars: 200 μm.