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. 2011 Mar;4(2):228–239. doi: 10.1242/dmm.006130

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© 2011. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms

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Fig. 5. — Increased and disorganized bone and cartilage in induced SHP-2-deficient mice. Shown are representative images of L4 vertebrae and femora of moribund tamoxifen-injected ptpn11^fl/fl ert2-cre mice and ptpn11^fl/fl littermate controls. Mice were injected with tamoxifen at 7 weeks of age and analysis was performed at 12 weeks of age. Top and middle panels are stained with H&E, and bottom panels are stained with Alcian blue to highlight cartilage. Scale bars: 1 mm in top panels, 500 μm in L4 vertebrae middle panels, and 200 μm in femora middle panels and all bottom panels. The amount of trabecular bone (t) is dramatically increased in ptpn11^fl/fl ert2-cre vertebrae and femora. A region of remodeled (r) cortical bone (c) in femora of ptpn11^fl/fl ert2-cre mice shows disorganized bone in this region compared with the same region in the control. Remains of ectopic cartilaginous elements (e) were identified in the trabecular bone region and ectopic cartilage formation (cf) was identified next to growth plates (g) in ptpn11^fl/fl ert2-cre mice. The columnar formation of growth plates was disorganized in ptpn11^fl/fl ert2-cre mice and the area of hypertrophic chondrocytes (hc) was elongated.