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Blocking Notch signaling increases the number of EGFP-expressing cells in fetal pancreas explants. Pancreases were harvested from E11.5 embryos, placed in culture and treated with 50 mM DAPT in 0.1% DMSO (A) or 0.1% DMSO alone (B). After 48 hours of treatment, cultured pancreases were dispersed into single cells, pooled and sorted by FACS to quantify the number of EGFP-expressing cells. Cells are separated on the y-axis by side scatter (SSC) and on the x-axis by EGFP fluorescence.
