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Pharmacokinetic summary
| PK parameter | Dose level −1 (n = 6) | Dose level 1 (n = 6) | P value* |
|---|---|---|---|
| Cpss (mg/L) | |||
| Mean | 1.9 | 1.0 | 0.06 |
| SD | 0.8 | 0.5 | |
| Median | 1.8 | 0.9 | |
| Range | 1.1–3.4 | 0.6–2.0 | |
| CLsys(L/h) | |||
| Mean | 5.1 | 10.4 | 0.008 |
| SD | 1.8 | 3.2 | |
| Median | 5.2 | 11.6 | |
| Range | 3.4–6.4 | 4.0–12.4 | |
| AUC (mg/L h) | |||
| Mean | 643 | 347 | 0.06 |
| SD | 274 | 176 | |
| Median | 595 | 307 | |
| Range | 383–1,148 | 189–681 | |
Two-tailed t test
