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. 2011 Feb 28;6(2):e17023. doi: 10.1371/journal.pone.0017023

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Latasa, Cosgaya.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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RXR-γ downregulation is higher in the presence of axonal contact mimickers, while RAR-β upregulation was similar irrespective of the growth conditions. Isolated SCs were adapted for 24 hours to the absence of the axonal contact mimickers BPE and forskolin and subsequently treated for 48 hours with 1 µM RA in the presence or absence of 2 µM forskolin, 60 µg/ml BPE or the combination of both, and the mRNA levels of RAR-β (A) and RXR-γ (B) were analyzed by Q-RT-PCR. In all instances, the levels reached after the acute combined treatment were compared to SCs continuously grown in the presence of BPE and Fk (BPE+Fk always). All values are shown as the mean ± SEM relative to their respective controls.