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. 2011 Feb 28;6(2):e17023. doi: 10.1371/journal.pone.0017023

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Latasa, Cosgaya.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Myelinating cocultures were treated for 7 days with 1 µM of the natural retinoids all-trans-retinoic acid (RA) and 9-cis-retinoic acid (9-cis), or the synthetic compound TTNPB, and the relative mRNA levels of RAR-β and RXR-γ were determined by RT-Q-PCR. (B) Isolated SCs were treated for 48 hours with different doses of all-trans-retinoic acid (RA), TTNPB or 9-cis-retinoic acid (9-cis), and the relative levels of RAR-β and RXR-γ mRNAs were determined by RT-Q-PCR. All values are shown as the mean ± SD relative to their respective controls.