Table 2. Inhibitors with a z-score >2 from InhibitorSelect™ Library II.
Inhibitor | Position | AP-HB-EGF release | Surface AP-HB-EGF | ||
1 uM | 10 uM | 1 uM | 10 uM | ||
Cdk1/2 Inh. III | 8B | 1.8 | −2.4 | −0.2 | 2.7 |
K-252a | 4F | −4.7 | −3.8 | 3.6 | 3.8 |
SB218078 | 4H | −3.2 | −3.5 | 4.6 | 4.1 |
SB220025 | 6G | −0.4 | −2.8 | 0.1 | 3.3 |
Staurosporine | 8H | −2.9 | −3.5 | 6.5 | 5.0 |
Cdk1 Inh. | 7B | −0.7 | −2.7 | −0.1 | 1.6 |
Average z-score (n = 3) (calculated as standard deviations from DMSO-treated controls on each plate).