Figure 6. Host cell entry and cytotoxicity of rAbOmpA fragments.
(A) HeLa cells were treated with different forms of micelles containing rAbOmpA fragments for 24 h. The cells were fixed, permeabilized, and stained with anti-rabbit AbOmpA antibody, followed by Alexa Fluor® 568-conjugated rabbit IgG (red). DAPI was used to stain the nuclei (blue). The subcellular localization of AbOmpA was observed by confocal microscopy. Magnification: ×400. (B) The differentiated U937 cells were treated with different forms of micelles containing rAbOmpA fragments for 24 h. Cell viability was determined by a WST-1 assay. Untreated control cells (⧫), rAbOmpA22-170 (•), rAbOmpA1-356 (X), and rAbOmpA221-339 (▪).