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. 2011 Feb 28;6(2):e17230. doi: 10.1371/journal.pone.0017230

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Varshney et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Mechanism showing possible cascade displacement model in uremic toxin– drug system depicts allosteric effect of toxin when binding to site I and site II. Red colour: CTN binding to its high-affinity site, site I as shown by solid arrows; blue colour: CTN binding to its low-affinity site, site II as shown by dashed arrows. Hemodialytic reaction occurring within the blood plasma has been shown in red box.