Table 2.

Significant Differences in Medial Temporal Brain Regions Between Early Users of Hormone Therapy and Never Users.

		Talairach Coordinate
Condition, Direction of Effect		x	y	z	Brain Region	Z
Verbal Recognition
	Never>Early	−22	−35	−10	Left PHG, perirhinal, BA 36	3.48
		20	−30	−14	Right PHG, perirhinal, BA 35	3.24
	Early>Never	−26	−22	−7	Left Hippocampus	3.28
Verbal Encoding
	Never>Early				none
	Early>Never				none
Verbal Match
	Never>Early				none
	Early>Never	−30	−27	−4	Left Hippocampus	3.67
Verbal Encoding - Match
	Never>Early	−26	−24	−6	Left Hippocampus	3.18
	Early>Never				none
Verbal Recognition - Match
	Never>Early				none
	Early>Never				none
Figural Encoding
	Never>Early				none
	Early>Never				none
Figural Recognition
	Never>Early
	Early>Never	−16	−31	−3	Left PHG, perirhinal, BA 27/35	3.14
Figural Match
	Never>Early				none
	Early>Never				none
Figural Encoding - Match
	Never>Early				none
	Early>Never				none
Figural Recognition - Match
	Never>Early				none
	Early>Never	20	−33	−7	Right PHG, BA 35	3.02

Notes: Significant results presented for verbal and figural memory tasks for each condition alone and each condition contrasted with the other. Direction of effects indicates whether early HT users showed greater (>) or less (<) activation compared to never users. BA = Brodmann Area; PHG = parahippocampal gyrus; none = not available (no significant differences).