Table 12.
Success rates for correctly ranking the low-, medium-, and high-affinity ligands in the PDBbind 2007 core set for the PHOENIX scoring function and 16 other commonly used scoring functions taken from the Cheng et al. study29.
| Scoring function | Success rate (%) |
|---|---|
| PHOENIX | 46.2 |
| X-Score::HSScore | 58.5 |
| DS::PLP2 | 53.8 |
| DrugScoreCSD | 52.3 |
| SYBYL::ChemScore | 47.7 |
| SYBYL::D-Score | 46.2 |
| SYBYL::G-Score | 46.2 |
| GOLD::ASP | 43.1 |
| DS::LUDI3 | 43.1 |
| DS::Jain | 41.5 |
| DS::PMF | 41.5 |
| SYBYL::PMF-Score | 38.5 |
| GOLD::ChemScore | 36.9 |
| DS::LigScore2 | 35.4 |
| GlideScore-XP | 33.8 |
| Number of Heavy Atoms |
32.3 |
| SYBYL::F-Score | 29.2 |
| GOLD::GoldScore | 23.1 |