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. 2011 Feb 28;6(2):e17578. doi: 10.1371/journal.pone.0017578

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Chen et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Representative images of cytoplasmic Skp2 immunohistochemical staining in human melanocytic lesions. (A and C) Low cytoplasmic Skp2 staining, (B and D) High cytoplasmic Skp2 staining. (E) Cytoplasmic Skp2 expression is increased from normal nevi to dysplastic nevi and melanoma. Significant differences for Skp2 staining are observed between normal and dysplastic nevi (P = 0.039, χ² test), dysplastic nevi and primary melanoma (P = 0.008, χ² test), and primary and metastatic melanoma (P = 0.008, χ² test). NN, normal nevi; DN: dysplastic nevi; PM: primary melanoma; MM: metastatic melanoma. Magnification: ×100 for A and B; ×400 for C and D.