Table 3. Multivariate Cox regression analysis on overall and disease-specific 5-year survival of 259 primary melanoma patients.

Variables*	Overall survival					Disease-specific survival
	β†	SE	HR	95% CI	P ‡	β†	SE	HR	95% CI	P ‡
Age	0.544	0.278	1.74	1.01–3.02	0.046	0.282	0.289	1.33	0.75–2.34	0.329
Sex	0.012	0.254	1.01	0.62–1.66	0.964	–0.060	0.276	0.94	0.55–1.62	0.828
Thickness	1.035	0.295	2.82	1.58–5.02	<0.001	1.241	0.324	3.46	1.83–6.53	<0.001
Ulceration	0.908	0.282	2.48	1.43–4.31	0.001	0.884	0.301	2.42	1.34–4.37	0.003
Location	–0.091	0.292	0.91	0.52–1.62	0.755	0.100	0.301	1.11	0.61–2.00	0.740
Cytoplasmic Skp2	0.124	0.258	1.13	0.68–1.88	0.629	0.177	0.277	1.19	0.69–2.05	0.523

*Coding of variables: Age was coded as 1 (≤60 years) and 2 (>60 years). Sex was coded as 1 (male) and 2 (female). Thickness was coded as 1 (≤2.00 mm) and 2 (>2.00 mm). Ulceration was coded as 1 (absent) and 2 (present). Location was coded as 1 (sun-protected) and 2 (sun-exposed). Cytoplasmic Skp2 was coded as 1 (low staining) and 2 (high staining).

^†β: regression coefficient.

^‡Log-Rank test.

Abbreviations: SE, standard error of β; HR, hazard ratio; CI, confidence interval.