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DNA relaxation is mediated by topoisomerases. We incubated a supercoiled plasmid, pBR322 with isolated topoisomerare II in the presence of increasing concentrations of voreloxin. DNA migrates through agarose gels more slowly in its relaxed state so the presence of increasing levels of super-coiled DNA with increasing voreloxin concentration (μM) illustrates that voreloxin is acting on the action of topoisomerase II.
