Figure 1.
FL (dark bars) and RL constructs (light bar). CGG repeats are located within FMR1 and synthetic 5′UTRs and have the following CGG-repeat lengths (n): 0, 16, 30, 62, 99 CGG. FMR15′UTR(HP)-FL and synthetic 5′UTR(HP)-FL have a strong hairpin (HP) replacing the CGG element. 5′HP-FMR15′UTR(30 CGG)-FL, 5″HP-FMR15′UTR(30 CGG)-FL, and 5′HP-synthetic 5′UTR(30 CGG)-FL each have a strong HP at the 5′ ends of the mRNAs. FL and RL messages are transcribed via SP6 and T7 promoters, respectively.
