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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: J Autoimmun. 2011 Jan 22;36(2):155–160. doi: 10.1016/j.jaut.2010.12.004

Fig. 1.

Fig. 1

Kinetic stability of peptide:MHC complex composed by DR0401 or DR0403 with selected GAD65 derived peptides. (A) DQ8 bound GAD65 peptides also bind DR0401 (within black line circle) and/or DR0403 (within blue line circle). The dissociation of GAD65p24 (B), p25 (C), p26 (D), p34 (E), p42 (F) and p67 (G) from HLA-DR0401 (black circles, solid lines) and HLA-DR0403 (open circles, dotted lines) was measured as the remaining amount of biotinylated target peptides against experimental time. The dissociation curves were generated with a single-exponential decay fit [Equation: Y= Span*exp(−Kd*X)+Plateau].