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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: J Autoimmun. 2011 Jan 26;36(2):142–154. doi: 10.1016/j.jaut.2010.12.005

Figure 5. Accumulation of high numbers of Tregs in the CNS of SJL/J, but not C57BL/6 mice during acute TMEV infection.

Figure 5

Foxp3-GFP transgenic SJL/J and B6 mice were sham infected or infected i.c. with 5×106 PFU/mouse of TMEV on day 0. At days 3 and 7 PI, the numbers of CD3+CD4+Foxp3+ Treg cells were enumerated in the CNS (A) and spleen (B) by using the percentage of cells to back calculate the number of live cells as determined by trypan blue exclusion. The numbers of Tregs in the CNS of TMEV-infected SJL/J mice were significantly higher than those in the CNS of sham infected SJL/J mice and of TMEV-infected B6 mice (*p<0.01), (**p<0.03). This data is representative of 5–6 individual experiments.

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