Figure 6. The ratio of activated CD8⁺ T cells to Treg cells is less in the CNS of TMEV-infected SJL/J mice than C57BL/B6 mice.

Foxp3-GFP transgenic SJL/J and B6 mice were infected i.c. with 5×10⁶ PFU/mouse of TMEV on day 0. At days 3 and 7 PI, the numbers of IFN-γ-producing CD8⁺ effector T cells (CD3⁺CD8⁺IFN-γ⁺) and Treg cells (CD3+CD4⁺Foxp3⁺) were enumerated in the CNS (A) and spleen (B). The ratio of Treg cells (CD3⁺CD4⁺Foxp3⁺) and activated effector cells (CD3⁺CD8⁺CD25⁺CD62L^lo) were also enumerated in the CNS (C). The ratio of activated CD8⁺ T cells to Treg cells was then determined and is shown above each pair of bars. Data represents the mean ± SD of 4 mice per group on day 3 and 5 mice per group on day 7 post-infection. This data is representative of 2 individual experiments.