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Mean indifference points for Lewis rats (upper panel) and Fischer 344 rats (lower panel) under non-drug (control vs. withdrawal) conditions and following acute and repeated administration of saline or nicotine (0.1, 0.3, 1.0 mg/kg). Values are means (± SEM) and asterisks indicate statistically significant differences from acute means at the same dose (p < 0.05).
