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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Biochim Biophys Acta. 2010 Dec 21;1813(3):403–411. doi: 10.1016/j.bbamcr.2010.12.013

Fig. 6. NRF-1 over-expression in primary neurons significantly increased mRNA levels for Kif17 and Grin1 genes and rescued them from TTX-induced suppression. Grin1, Kif17, and Kif1a mRNA levels.

Fig. 6

(A–C) were all reduced by TTX as compared to controls. Over-expression of NRF-1 significantly increased transcript levels of Grin1 and Kif17, but not of Kif1a. Over-expression of NRF-1 was able to rescue Grin1 and Kif17, but not Kif1a from TTX-induced down-regulation. Group means were analyzed for overall statistical significance using the Student’s t-test (N = 6 for each group). All * P values were compared to empty vectors (* P < 0.05). All # P values were compared to empty vector plus TTX (# P < 0.05), and all X P values were compared to NRF-1 over-expression (X P < 0.05). (D) Protein levels for KIF17 and KIF1A were all reduced with TTX impulse blockade as compared to controls in neurons. However, NRF-1 over-expression rescued protein levels of KIF17, but not of KIF1A, from being down-regulated by TTX. All * P values were compared to controls (* P < 0.01). All #P values were compared to TTX (#P < 0.01).