Table 5.
Overall Positive Predictive Value and Negative Predictive Value (95% Confidence Intervals) Comparisons
| |
High fasting insulin (>28.0) (n = 156) |
High HbA1c (>5.5) (n = 305) |
High hsCRP (>4.0) (n = 170) |
High uric acid (>7.3) (n = 116) |
One or more elevations (n = 609) |
Two or more elevations (n = 108) |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Set of Metabolic syndrome criteria | PPV | NPV | PPV | NPV | PPV | NPV | PPV | NPV | PPV | NPV | PPV | NPV |
| IDF | 50.0 | 96.8 | 15.4 | 91.6 | 16.9 | 95.2 | 40.1 | 96.2 | 80.0 | 82.1 | 30.5 | 98.0 |
| (38.7, 61.3) | (95.8, 97.6) | (7.1, 30.1) | (89.6, 93.3) | (7.2, 34.7) | (93.7, 96.3) | (26.4, 55.6) | (95.0, 97.1) | (67.9, 88.3) | (79.7, 84.3) | (20.0, 43.5) | (97.2, 98.5) | |
| Cook | 38.0 | 97.3 | 14.5 | 91.8 | 13.6 | 95.3 | 30.4 | 96.5 | 65.7 | 82.8 | 23.1 | 98.3 |
| (28.1, 49.0) | (96.3, 98.0) | (7.7, 25.7) | (89.7, 93.4) | (8.1, 21.8) | (93.9, 96.3) | (21.8, 40.7) | (95.4, 97.4) | (53.9, 75.8) | (80.4, 85.1) | (15.9, 32.4) | (97.6, 98.8) | |
| Ford | 34.0 | 97.5 | 14.1 | 91.8 | 12.4 | 95.3 | 25.7 | 96.6 | 59.8 | 83.1 | 20.2 | 98.3 |
| (25.6, 43.7) | (96.6, 98.2) | (7.6, 24.7) | (89.8, 93.5) | (7.5, 20.0) | (93.9, 96.4) | (17.4, 36.3) | (95.4, 97.4) | (48.9, 69.8) | (80.6, 85.3) | (13.6, 28.8) | (97.7, 98.8) | |
| Jolliffe(ATP III) | 37.8 | 97.3 | 14.1 | 91.7 | 15.9 | 95.4 | 26.9 | 96.3 | 64.9 | 82.9 | 22.4 | 98.2 |
| (29.1, 47.3) | (96.3, 98.0) | (7.7, 24.4) | (89.7, 93.4) | (8.8, 27.1) | (94.0, 96.6) | (17.5, 38.9) | (95.0, 97.3) | (54.3, 74.2) | (80.4, 85.0) | (14.8, 32.3) | (97.6, 98.7) | |
| Jolliffe(IDF) | 31.8 | 97.4 | 12.9 | 91.7 | 14.0 | 95.5 | 22.8 | 96.4 | 57.7 | 83.1 | 17.9 | 98.2 |
| (24.5, 40.1) | (96.5, 98.1) | (7.2, 22.1) | (89.7, 93.4) | (8.1, 23.2) | (94.1, 96.5) | (14.8, 33.4) | (95.1, 97.3) | (48.1, 66.6) | (80.6, 85.3) | (11.8, 26.3) | (97.5, 98.7) | |
| DeFerranti | 23.4 | 98.2 | 12.1 | 92.0 | 10.9 | 95.7 | 18.6 | 97.1 | 47.4 | 84.4 | 13.7 | 98.7 |
| (17.6, 30.3) | (97.7, 98.6) | (7.8, 18.2) | (89.7, 93.8) | (7.2, 16.2) | (94.4, 96.7) | (12.9, 26.2) | (96.0, 98.0) | (39.9, 55.1) | (81.9, 86.7) | (9.8, 18.7) | (98.1, 99.1) | |
Abbreviations: HbA1c, hemoglobin Ale; hsCRP, high-sensitivity C-reactive protein; PPV, positive predictive value; NPV, negative predictive value; IDF, International Diabetes Federation; ATP, Adult Treatment Panel III.