Table 2.
Geometric mean (95% confidence interval) hormone concentrations in prediagnostic serum from casesa and matched controls
| Cases | Controls | ||||||
|---|---|---|---|---|---|---|---|
| n | Mean | 95% CI | n | Mean | 95% CI | P b | |
| Estradiol, pg/ml | 98 | 85.8 | 72.5-101.5 | 168 | 80.3 | 70.5-91.6 | 0.62 |
| Bioavailable estradiol, pg/ml | 98 | 49.9 | 42.1-59.0 | 168 | 45.7 | 40.2-51.9 | 0.46 |
| Testosterone, ng/dl | 98 | 28.1 | 26.2-30.1 | 168 | 24.7 | 23.3-26.1 | 0.005 |
| Bioavailable testosterone, ng/dl | 98 | 11.8 | 10.8-12.8 | 168 | 10.1 | 9.5-10.7 | 0.002 |
| SHBG, nmol/L | 98 | 55.2 | 50.4-60.4 | 168 | 57.7 | 53.7-62.0 | 0.34 |
All variables are continuous. CI, confidence interval; SHBG, sex hormone-binding globulin. aMean (± SD) time from blood collection to diagnosis was 14.0 ± 6.6 years. bP values (two-sided) were calculated by using conditional logistic regression with log-transformed hormone and SHBG levels entered as a linear term to test for trend by using a Wald test.