Table 2.
Renal parameters and outcome measures at baseline, at the end of the induction treatment and at the latest follow-up
| Parameters | At baseline | At the end of the induction therapy | P* | At the latest follow-up | P* | P** |
|---|---|---|---|---|---|---|
| GFR (ml/minute/1.73 m2) | 74 (21 to 156) | 82 (27 to 184) | 0.008 | 84 (33 to 156) | 0.009 | 0.095 |
| No of pts with low GFR (<80 ml/minute/1.73 m2) | 19 (58) | 15 (45) | 0.049 | 9 (27) | 0.001 | 0.070 |
| GFR only in pts with low levels (ml/minute/1.73 m2) | 62 (21 to 79) | 58 (27 to 79) | 0.393 | 63 (33 to 79) | 0.374 | 0.059 |
| Acute renal failure | 5 (15) | 0 | 0 | |||
| Proteinuria (g/24 h) | 1.7 (0.2 to 10.6) | 0.8 (0 to 7.1) | <0.001 | 0.3 (0 to 4.7) | 0.001 | 0.155 |
| No of pts with proteinuria (> 500 mg/24 h) | 29 (88) | 20 (61) | <0.001 | 14 (42) | 0.004 | 0.109 |
| > 3 g/24 h | 12 (36) | 6 (18) | 5 (15) | |||
| 1 to 3 g/24 h | 9 (27) | 7 (21) | 6 (18) | |||
| Hematuria (> 5 hpf) | 29 (88) | 12 (36) | <0.001 | 11 (33) | <0.001 | 1.00 |
| Pyuria (> 5 hpf) | 18 (54) | 11 (33) | <0.001 | 7 (21) | 0.001 | 0.219 |
| Cellular Casts (> 1 hpf) | 10 (30) | 2 (6) | <0.001 | 3 (9) | 0.065 | 1.00 |
| Active urine sediment | 29 (88) | 13 (39) | <0.001 | 11 (33) | <0.001 | 0.754 |
| Hypertension (Systolic pressure > 140 or diastolic > 90 mmHg) | 7 (21) | 3 (9) | 0.180 | 3 (9) | 0.70 | 1.00 |
| ECLAM score | 8.2 (2.5 to 13.5) | 2.7 (0 to 7) | <0.001 | 2.5 (0 to 7.5) | <0.001 | 0.165 |
| Remission | 15 (45) | - | 24 (73) | - | <0.001 | |
| Complete remission | 8 (24) | - | 19 (58) | - | <0.001 | |
| Disease remission | 4 (12) | - | 17 (51) | - | <0.001 | |
| Renal relapse | 0 | - | 4 (12) | - | 0.125 |
* compared to baseline, ** compared to the end of the induction treatment. Values are expressed as either proportions or median (range).
GFR, glomerular filtration rate; ECLAM, European Consensus Lupus Activity Measurement; hpf, high power field.