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. 2010 Dec 17;12(6):301. doi: 10.1186/ar3196

Figure 2.

Figure 2

The entheseal stress hypothesis for the relationship between inflammation and ankylosis in spondyloarthritis. BMP, bone morphogenetic protein; DISH, diffuse idiopathic skeletal hyperostosis; FOP, fibrodysplasia ossificans progressiva; IBD, inflammatory bowel disease; ERAP, endoplasmic reticulum aminopeptidase. Reproduced with permission from Lories RJ, Luyten FP, de Vlam K: Progress in spondylarthritis. Mechanisms of new bone formation in spondyloarthritis. Arthritis Res Ther 2009, 11:221 [19].