Table 3.
Genes with the most discordant changes in expression in Mmp8+/+ and Mmp8-/-arthritic mice
| Gene | Fold change: CRL Mmp8 -/- vs. RA Mmp8 -/- (A) | Fold change: CRL Mmp8 +/+ vs. RA Mmp8 +/+ (B) | Ratio A/B |
|---|---|---|---|
| Anpep | 2.107 | 3.766 | 0.559 |
| Arsi | 3.440 | 4.685 | 0.734 |
| Aspa | 0.289 | 0.195 | 1.481 |
| C1qtnf3 | 5.773 | 8.349 | 0.691 |
| Capn6 | 5.503 | 11.324 | 0.485 |
| Ces3 | 0.050 | 0.074 | 0.682 |
| Csgalnact1 | 4.318 | 5.906 | 0.731 |
| Ddefl1 | 1.411 | 2.010 | 0.702 |
| Fbln2 | 2.254 | 3.128 | 0.720 |
| Gltd5d1 | 1.411 | 2.158 | 0.654 |
| Grb10 | 1.639 | 2.421 | 0.677 |
| H19 | 3.154 | 5.834 | 0.541 |
| Ifitm1 | 2.100 | 4.232 | 0.496 |
| Il1 β | 5.014 | 3.711 | 1.351 |
| Itga5 | 2.184 | 3.079 | 0.709 |
| Mmp3 | 27.264 | 41.104 | 0.663 |
| Nt5dc2 | 3.532 | 4.891 | 0.722 |
| P4ha3 | 6.826 | 9.504 | 0.718 |
| Postn | 2.949 | 4.571 | 0.645 |
| Prokr2 | 4.791 | 3.527 | 1.358 |
| Ptgfrn | 1.705 | 2.407 | 0.708 |
| Ptx3 | 6.117 | 4.493 | 1.361 |
| Rentla | 0.031 | 0.043 | 0.709 |
| Sfrp1 | 8.278 | 11.900 | 0.696 |
| Slc39a14 | 5.882 | 7.949 | 0.739 |
| Sult1a1 | 0.251 | 0.181 | 1.379 |
| Syne2 | 0.590 | 0.335 | 1.759 |
| TenascinN | 3.653 | 5.793 | 0.631 |
| Tpd52 | 2.410 | 1.781 | 1.353 |
Genes with the most discordant changes (<0.75 or >1.35) in expression in Mmp8+/+ and Mmp8-/-arthritic mice in relation to their respective nonarthritic controls (selected from arthritis-associated genes according to Bonferroni-corrected P < 0.01). Bold genes were chosen for confirmatory real-time PCR. CRL, control; RA, rheumatoid arthritis.