Table 1.
Neuropsychological and Demographic Characteristics of Patients and Controls.
| AD | bvFTD | SD | NC | Overall ANOVA | |
|---|---|---|---|---|---|
| n | 17 | 12 | 6 | 21 | |
| Gender (m/f) | 7/10 | 10/2 | 2/4 | 8/13 | |
| Age (years) | 62.4 ± 7.7 | 61.2 ± 7.7 | 66.8 ± 6.0 | 60.7 ± 10.3 | NS |
| Mini Mental Status Examination (max = 30) | 21.5 ± 5.3^* | 26.9 ± 2.7 | 24.0 ± 3.1* | 29.2 ± 0.9 | F (3,5) = 17.1 |
| Education (years) | 15.8 ± 2.6 | 15.3 ± 3.2 | 14.5 ± 1.8 | 16.7 ± 2.1 | NS |
| Clinical Dementia Rating Scale (CDR) (max = 3) | 0.85 ± 0.39* | 0.91 ± 0.44* | 0.83 ± 0.26* | 0.03 ± | F (3,50) = 30.8 |
| CDR sum of cognitive-functional impairment (max = 18) | 4.79 ± 2.10* | 5.45 ± 2.01* | 5.17 ± 2.07* | 0.10 ± | F (3,50) = 38.6 |
| Geriatric Depression Scale (max =30) | 9.14 ± 7.26 | 6.45 ± 5.85 | 11.0 ± 6.99 | 3.24 ± | F (3,48) = 4.9 |
| Memory | |||||
| Modified Rey Recall (max = 18) | 5.18 ± 3.84^* | 10.8 ± 2.7 | 8.50 ± 5.4 | 11.8 ± 2.6 | F (3,52) = 12.9 |
| Language | |||||
| Boston Naming Test (max = 15) | 11.3 ± 4.4 | 12.4 ± 1.7 | 3.00 ± 3.03#^* | 14.3 ± 1.0 | F (3,50) = 26.0 |
| Verbal Repetition (max = 3) | 2.31 ± 0.95 | 2.83 ± 0.39 | 2.67 ± 0.52 | 2.90 ± | NS |
| Visuospatial | |||||
| Modified Rey Copy (max = 18) | 10.2 ± 5.6^@* | 14.6 ± 1.6 | 16.0 ± 0.6 | 15.3 ± 0.9 | F (3,52) = 9.9 |
| Calculations (max = 5) | 3.06 ± 1.30* | 3.83 ± 0.94 | 3.83 ± 0.75 | 4.85 ± 0.49 | F (3,51) = 11.6 |
| Executive, Attention, Speed & Working Memory | |||||
| Digits Backward (number) | 3.12 ± 1.36* | 4.08 ± 1.44* | 4.17 ± 1.17 | 6.11 ± 1.45 | F (3,50) = 14.4 |
| Modified Trails Time (seconds) | 85.1 ± 39.3* | 54.3 ± 30.3 | 52.8 ± 32.9 | 31.5 ± 13.6 | F (3,47) = 9.7 |
| Modified Trails Correct (number of lines) | 9.29 ± 5.85* | 12.9 ± 3.62 | 14.0 ± 0.00 | 14.0 ± | F (3,47) = 5.6 |
| Design Fluency Correct (number) | 5.81 ± 3.83* | 5.75 ± 2.93* | 7.00 ± 3.22 | 10.7 ± 3.6 | F (3,51) = 8.1 |
| Design Fluency Repetitions (number) | 1.06 ± 1.39 | 5.25 ± 5.94#* | 2.50 ± 2.59 | 1.00 ± 1.26 | F (3,51) = 5.7 |
| Stroop Color Naming (number) | 41.9 ± 24.8* | 60.0 ± 13.7 | 58.2 ± 16.4 | 82.8 ± 16.9 | F (3,47) = 13.9 |
| Stroop Interference (number) | 17.1 ± 15.6 | 35.0 ± 14.0 | 32.0 ± 8.1 | 49.4 ± 10.9 | F (3,46) = 18.0 |
| D Words (number) | 7.24 ± 4.18* | 7.50 ± 3.32* | 4.00 ± 2.68* | 16.8 ± 5.5 | F (3,52) = 22.7 |
| Animals (number) | 9.82 ± 5.56* | 12.8 ± 4.5 | 4.67 ± 4.68* | 21.6 ± 5.1 | F (3,52) = 26.3 |
| Abstraction (max = 7) | 2.07 ± 1.39* | 2.33 ± 1.67* | 1.50 ± 1.00* | 4.55 ± 0.95 | F (3,47) = 15.2 |
| Compulsivity | |||||
| Distractibility + Aberrant motor behaviors score (Neuropsychiatric Inventory) | 4.00± 5.40^ | 13.55±6.52#* | 12.17 ± 9.30* | 0 ± 0 | F (3, 42) = 11.3 |
#
p < 0.01 vs. AD
^
p < 0.01 vs. bvFTD
@
p < 0.01 vs. SD
*
p < 0.01 vs. NC