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Development of an atherothrombotic lesion. A simplified depiction of the development of an atherothrombotic lesion, starting with a normal blood vessel (far left) to a ruptured plaque with superimposed thrombus (far right). AHA, American Heart Association; ICAM1, intercellular adhesion molecule 1; LDL, low-density lipoprotein; MMP, matrix metalloproteinase; VCAM1, vascular cell adhesion molecule 1. (Adapted from Sanz and Fayad [67])
