Fig. 5.

Effects of simvastatin on FDG uptake in atherosclerotic plaque inflammation. Representative FDG-PET images at baseline and after 3 months of treatment (post-treatment) with dietary intervention versus simvastatin. Baseline images demonstrate FDG uptake within a common carotid plaque (square). A substantial reduction in plaque FDG uptake is seen after 3 months of simvastatin (top). The bottom panel demonstrates per-subject data for baseline and post-treatment values in the diet and simvastatin groups. There was a significant reduction in vascular FDG uptake after simvastatin therapy but not after dietary modification. NS, not significant; SUV, standardized uptake value. (Modified from Tahara et al. [47]; with permission)