TABLE 3.
Meta-analysis results of observed and instrumental variable analyses of triglyceride–continuous outcome associations
| Trait |
Observed change in outcome z score per 1-SD increase in log10-triglycerides | Instrumental variable estimate of change in outcome z score per 1-SD increase in log10-triglycerides | ||||
|---|---|---|---|---|---|---|
| Effect size (95% CI) | P | Heterogeneity P (I2%) | Effect size (95% CI) | P | Heterogeneity P (I2%) | |
| Fasting insulin |
0.41 (0.38–0.43) |
<0.001 |
0.008 (74.6) |
0.04 (−0.08 to 0.16) |
0.49 |
0.12 (48.2) |
| Fasting glucose |
0.12 (0.10–0.15) |
<0.001 |
0.02 (69.5) |
0.01 (−0.10 to 0.12) |
0.90 |
0.002 (79.4) |
| HOMA-IR |
0.40 (0.38–0.42) |
<0.001 |
0.006 (75.7) |
0.04 (−0.08 to 0.16) |
0.51 |
0.13 (47.3) |
| HOMA-B | 0.36 (0.33–0.38) | <0.001 | 0.11 (49.7) | 0.01 (−0.11 to 0.13) | 0.83 | 0.27 (23.7) |
The sample sizes for the triglyceride vs. outcome associations ranged from 6,705 to 8,227 and from 6,519 to 8,040 for instrumental variable meta-analyses.