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. 2011 Feb 21;60(3):775–783. doi: 10.2337/db10-1416

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© 2011 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 3. — Acute endotoxemia induces hepatic and adipose tissue insulin resistance in BAC-Retn mice. A–C: Hyperinsulinemic-euglycemic clamp analysis of BAC-Retn (■) vs. Rko (□) mice (n = 4 per group) in 6 h after LPS administration. D and E: Rate of insulin-stimulated glucose uptake in WAT (D) and skeletal muscle (E). F: Total ceramides content in liver. G: Correlation between hepatic ceramide content and hepatic glucose production (HGP) during the clamp study. Data are presented with the SEM. GIR, glucose infusion rate; Rd, whole-body rate of glucose disposal. *P < 0.05 vs. saline; #P < 0.05 vs. Rko.