FIG. 4.

Impaired glucose tolerance and exacerbated inflammation in chronically endotoxemic BAC-Retn mice. A: With chronic LPS (2 mg/kg/day) subcutaneous infusion, BAC-Retn mice show impaired glucose tolerance compared with Rko mice (n = 5–7 per group). B and C: Serum resistin (B) and insulin (C) levels in Rko (□) and BAC-Retn (■) mice. D and E: Gene-expression analysis in liver (D) and skeletal muscle (E). Data are presented with the SEM. GTT, glucose tolerance test; RETN, human resistin. *P < 0.05, **P < 0.01 vs. saline; #P < 0.05, ##P < 0.01 vs. Rko.