FIG. 3.

Effect of GIBP surgery in WT and PyyKO mice. Male weight-matched DIO WT mice and PyyKO littermates underwent GIBP surgery or sham procedure. Ten days postoperatively mice were killed in the fasted state. Body weight (A), plasma leptin (B), plasma acyl-ghrelin (C), stomach ghrelin expression (D), plasma total PYY (E), colonic Pyy expression (F), plasma active GLP-1 (G), and colonic glucagon expression (H) were evaluated. Data are expressed as means ± SE. *P < 0.05; **P < 0.01; ††P < 0.01. WT.S, n = 7; WT.BP, n = 8; PyyKO.S, n = 8; PyyKO.BP, n = 7.