TABLE 1.
Effect of HFD on fasting body weight, plasma leptin, stomach expression of ghrelin and Mboat4, and colonic expression of Pyy and glucagon
| Weeks of diet |
||||||||
|---|---|---|---|---|---|---|---|---|
| 4 |
8 |
12 |
16 |
|||||
| Control | HFD | Control | HFD | Control | HFD | Control | HFD | |
| Body weight (g) | 24.5 ± 1.6 | 27.9 ± 0.7 | 28.0 ± 1.2 | 32.7 ± 1.2 | 28.4 ± 0.4 | 34.3 ± 1.1 | 29.9 ± 1.0 | 35.5 ± 1.1 |
| P < 0.05 | P < 0.01 | P < 0.001 | ||||||
| Leptin (ng/mL) | 0.6 ± 0.1 | 3.2 ± 1.0 | 0.8 ± 0.2 | 3.1 ± 1.0 | 1.2 ± 0.5 | 8.3 ± 2.7 | 1.0 ± 0.1 | 8.5 ± 2.1 |
| P < 0.05 | P < 0.05 | P < 0.01 | ||||||
| Stomach | ||||||||
| ghrelin (AU) | 1.1 ± 0.1 | 1.2 ± 0.1 | 1.0 ± 0.1 | 1.1 ± 0.1 | 1.3 ± 0.1 | 1.3 ± 0.1 | 1.4 ± 0.1 | 1.3 ± 0.1 |
| Stomach | ||||||||
| Mboat4 (AU) | 0.7 ± 0.5 | 0.7 ± 0.1 | 0.7 ± 0.1 | 0.6 ± 0.1 | 0.7 ± 0.1 | 0.6 ± 0.1 | 0.8 ± 0.1 | 0.7 ± 0.1 |
| Colonic Pyy (AU) | 1.1 ± 0.1 | 1.2 ± 0.1 | 1.1 ± 0.1 | 1.2 ± 0.1 | 1.2 ± 0.1 | 1.0 ± 0.1 | 1.0 ± 0.1 | 1.2 ± 0.1 |
| Colonic | ||||||||
| glucagon (AU) | 1.0 ± 0.1 | 1.2 ± 0.1 | 1.2 ± 0.1 | 1.2 ± 0.1 | 1.2 ± 0.1 | 1.0 ± 0.1 | 1.0 ± 0.1 | 1.2 ± 0.1 |
Data are means ± SE. Body weights and fasting expression of stomach ghrelin and Mboat4 and colonic Pyy and glucagon after 4, 8, 12, and 16 weeks' exposure to control diet or HFD.