TABLE 2.
Responsivity to glucose of first phase (Φ1), second phase (Φ2), basal insulin secretion (Φb), insulin sensitivity (SI), and glucose effectiveness (SG) in controls and monkeys administered STZ at baseline, biopsy, and euthanasia studies
| Control group |
STZ group |
|||||
|---|---|---|---|---|---|---|
| Baseline | Biopsy | Euthanasia | Baseline | Biopsy | Euthanasia | |
| Φ1 [109] | 125 ± 29 | 289 ± 66+ | 145 ± 43 | 107 ± 30 | 0 ± 0*+ | 0 ± 0*† |
| Φ2 [109 min−1] | 8 ± 3 | 9 ± 4 | 4 ± 3 | 7 ± 6 | 0 ± 0 | 0 ± 0 |
| Φb [109 min−1] | 6.4 ± 0.9 | 9.3 ± 1.9 | 5.2 ± 1.1¶ | 8.4 ± 2.3 | 0.8 ± 0.2*+ | 0.8 ± 0.3*† |
| SI [10−4 L pmol−1 min−1] | 1.4 ± 0.2 | 1.6 ± 0.4 | 1.3 ± 0.5 | 1.9 ± 0.6 | 0 ± 0*+ | 0 ± 0*† |
| SG [min−1] | 2.5 ± 0.2 | 2.5 ± 0.3 | 2.2 ± 0.2 | 2.7 ± 0.4 | 2.7 ± 0.2 | 2.7 ± 0.3 |
*Control vs. STZ, P < 0.05.
+Baseline vs. biopsy, P < 0.05.
†Baseline vs. euthanasia, P < 0.05.
¶Biopsy vs. euthanasia, P < 0.05.