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. 2011 Feb 21;60(3):867–875. doi: 10.2337/db10-1157

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© 2011 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 3. — IL-21 neutralization modulates activated T_H subsets. IL-17–expressing cells shown as representative dot plots (A) and quantified in the pancreas of treated vs. control mice on day 3 of treatment with IL-21R/Fc (B), as percentage of CD45+ cells, where n = 12 per group compiled from five experiments. Absolute number of Foxp3+ CD25+ CD4+ T-cells in pancreatic lymph node on days of treatment with IL-21R/Fc shown (C), and in pancreas on day 60 after treatment with IL-21R/Fc (D). Data are presented as means ± SEM, where n = 5 per group from two experiments.