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. 2011 Feb 21;60(3):867–875. doi: 10.2337/db10-1157

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© 2011 by the American Diabetes Association.

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FIG. 6. — Restoring CD8 T-cell responsiveness to IL-21 results in rapid islet allograft rejection. A: Percent islet graft survival in B6 and Il21r^−/− mice, and Il21r^−/− mice reconstituted with 1 million IL-21R competent CD8+ T-cells on day −4 (+CD8 T-cells), after allogenic islet transplants (day 0) (BALB/c donors). n = 5 for control B6 group, mean survival time of 16.7 days. n = 6 for Il21r^−/− group. n = 5 for Il21r^−/− (+CD8 T-cells) group. B: Individual blood glucose readings are shown for a cohort of B6 and Il21r^−/− (+CD8 T-cells) mice.