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. 2011 Feb 21;60(3):960–968. doi: 10.2337/db10-1361

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© 2011 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 1. — Time course of changes in UAE and PPARδ mRNA and protein expression in the kidneys. A: The UAE increased progressively in the untreated diabetic (DM) group during the 8-week observation period after the induction of diabetes. GW0742 treatment (DM+GW0742) significantly reduced UAE at 8 weeks compared with the DM group. Control, nondiabetic control mice. Data are means ± SE. *P < 0.01 for DM vs. DM+GW0742. B: Renal PPARδ mRNA expression was significantly increased in the DM group compared with the control group. Data are means ± SE. *P < 0.05. C: Localization of renal PPARδ protein expression by immunohistochemistry. PPARδ protein expression was predominantly localized in the glomeruli of the DM and DM+GW0742 groups. Original magnification ×400. D: Localization of renal Bcl-6 protein expression by immunohistochemistry. Bcl-6 protein was mainly expressed in the glomeruli of the control group, but its expression was suppressed in the DM group. The expression of Bcl-6 recovered in the DM+GW0742 groups compared with the DM group. Original magnification ×400. (A high-quality digital representation of this figure is available in the online issue.)