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. 2011 Feb 21;60(3):960–968. doi: 10.2337/db10-1361

FIG. 5.

FIG. 5.

High glucose suppresses Bcl-6 expression in RAW macrophages. A: mRNA isolated from macrophages was analyzed by quantitative RT-PCR. Bcl-6 expression was normalized to GAPDH. Data are means ± SE. *P < 0.05. B: High glucose increases and GW0742 decreases macrophage PPARδ protein expression. PPARδ expression was normalized to that of TBP. Data are means ± SE. *P < 0.05. C: Bcl-6 protein expression and PPARδ–Bcl-6 interaction in macrophages in response to high glucose and/or GW0742. The Bcl-6–PPARδ interaction was analyzed by Western blotting of total and PPARδ-bound Bcl-6 in macrophage nuclear proteins after pull-down assays. Bcl-6 expression was normalized to that of TBP. Data are means ± SE. *P < 0.05.