Table II.
Changes in high spin heme signals from baseline to 2, 4.5 and 22 h after 3-AP administration (g=6), expressed as ratios over baseline signals.
| Time | No. | Median | Range | Mean | SD | p-value |
|---|---|---|---|---|---|---|
| Baseline - 2 h | 16 | 16.81 | 0.67–151.0 | 32.27 | 42.24 | 0.002a |
| Baseline - 4.5 h | 18 | 1.00 | 0.02–71.0 | 10.55 | 20.93 | 0.020a |
| Baseline - 22 h | 18 | 1.00 | 0.02–148.0 | 14.22 | 36.29 | 0.040a |
Increased levels of heme after treatment suggest potential redox mechanisms involving cytochrome c release from the mitochondria. Unit of outcome variable – ratio over baseline. Baseline (denominator of ratio): value at time-point 0.
a
p-value of <0.05 obtained by Wilcoxon Signed Rank test (Ha ratio >1).