Table III.
Changes in high spin non-heme Fe from baseline to 2, 4.5 and 22 h after 3-AP administration (g=4.3), expressed as ratios over baseline signals.
| Time | No. | Median | Range | Mean | SD | p-value |
|---|---|---|---|---|---|---|
| Baseline - 2 h | 16 | 1.22 | 0.04–65.00 | 7.98 | 18.58 | 0.05 |
| Baseline - 4.5 h | 18 | 1.18 | 0.04–44.00 | 5.65 | 12.92 | 0.07 |
| Baseline - 22 h | 18 | 1.31 | 0.01–79.00 | 12.03 | 25.31 | 0.04a |
Increased levels of non-heme Fe, comprised mostly of Fe-transferrin signals, indicate inhibition of RR at later time-points. Unit of outcome variable – ratio over baseline. Baseline (denominator of ratio): value at time-point 0.
a
p-value of <0.05 obtained by Wilcoxon Signed Rank test (Ha ratio >1).