Figure 5.

Radioimmunotherapy of 2A3 tumors in mice. Mice with tumors measuring 0.5-0.7 cm in diameter were randomized into groups of five. The groups were treated IP with either: 200 μCi ¹⁸⁸Re-C1P5 mAb, matching amount (6 μg) of "cold" C1P5 mAb; or left untreated. Mice were observed for tumor growth and survival for 15 days. The experiment was performed twice. The differences in the tumor sizes between ¹⁸⁸Re-C1P5 mAb and untreated group were significant (P < 0.05) for all time points; the differences in the tumor sizes between ¹⁸⁸Re-C1P5 mAb and "cold" C1P5 mAb group were significant (P < 0.05) for Day 3-9 time points.