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The major differences in the crystal structures of IpaD (purple) and SipD (green) are in the packing of the N-terminal α-helical hairpin with the coiled coil. (A) The SipD α-helical hairpin packs on the central coiled coil at a different angle of 18° compared to the α-helical hairpin of IpaD, and (B) the SipD helix α3 pack at a different angle of 26° compared to helix α3 of IpaD (also, helix α4 of IpaD is longer by one turn).
