Table II.
Btk Interacting Proteins Identified by TAP and Mass Spectrometry
| UniProt/IPI | Protein Name | MWa | Xcorrb | Known Functionc |
|---|---|---|---|---|
| P23396/IPI00011253 | 40S ribosomal protein S3 | 26,671 | 90.3 | Protein translation machinery |
| Q9Y4W6/IPI00001091 | AFG-like protein | 88,528 | 40.2 | ATP-dependent protease |
| P68133/IPI00021428 | Alpha skeletal actin | 42,023 | 216.4 | Contraction |
| P12814/IPI00013508 | Alpha-actinin | 102,993 | 60.2 | Myofilament (actin) anchoring protein |
| P25705/IPI00440493 | ATP synthase alpha subunit | 59,713 | 210.3 | ATP production in mitochondria |
| P06576/IPI00303476 | ATP synthase beta subunit | 56,524 | 140.3 | ATP production in mitochondria |
| Q9BYX7/IPI00888712 | Beta-actin | 41,988 | 178.3 | Cytoskeleton |
| B4DMH3/IPI00798401 | Coronin-1C | 49,347 | 30.3 | Cytokinesis, cell motility |
| O00571/IPI00215637 | DDX3X, ATP-dependent RNA helicase | 73,198 | 30.2 | Nucleotide-binding, RNA processing |
| Q16643/IPI00003406 | Drebrin | 71,381 | 30.3 | Cell migration |
| Q05639/IPI00014424 | Elongation factor 1 alpha | 50,438 | 30.2 | Promotes t-RNA binding to ribosome |
| P21333/IPI00302592 | Filamin-A | 279,841 | 30.2 | Anchors cytoskeleton to membrane |
| P04406/IPI00219018 | Glyceraldehyde-3-phosphate dehydrogenase | 36,030 | 40.2 | Glycolytic enzyme |
| Q86YZ3/IPI00398625 | Hornerin | 282,226 | 40.3 | Epidermis formation |
| P13647/IPI00009867 | Keratin, type II | 62,340 | 250.3 | Cytoskeletal structure |
| Q9H1R3/IPI00221127 | Myosin light chain kinase 2 | 64,644 | 40.2 | Regulates contraction of striated muscle |
| P28331/IPI00604664 | NADH-ubiquinone oxidoreductase | 80,945 | 50.3 | Mitochondrial respiratory chain |
| P23246/IPI00010740 | SFPQ, splicing factor | 76,101 | 110.2 | Nucleotide-binding, spliceosome formation |
| P02549/IPI00220741 | Spectrin, alpha chain | 279,998 | 40.2 | Cytoskeletal structure |
| P40939/IPI00031522 | Trifunctional enzyme, alpha subunit | 82,947 | 70.3 | Fatty acid metabolism |
| P68366/IPI00007750 | Tubulin, alpha 4A chain | 49,892 | 30.2 | Major constituent of microtubules |
| P68371/IPI00007752 | Tubulin, beta 2C chain | 49,799 | 38.3 | Major constituent of microtubules |
| Q12792/IPI00183508 | Twinfilin | 43,890 | 40.3 | Actin binding, polymerization |
a
Molecular weight, as calculated from amino acid sequence.
b
As determined by SEQUEST from highest single run in which protein was identified.
c
Determined from UniProt annotation.