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Pharmacodynamics of CP-870,893 after first, second and fourth infusion of CP-870,893. Parameters are shown relative to baseline. CD19 (%+) = percentage of CD19+ cells among lymphocytes, CD19 (abs) = absolute number of CD19+ cells, CD54 (%+) = CD54+ cells among CD19+ cells, CD86 (%+) CD86+ cells among CD19+ cells. Arrows indicate treatment days (day 1, 8, 15, 22). Values expressed as mean ± SEM, n = 8–18.
