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. 2011 Jan 1;11(1):50–57. doi: 10.4161/cbt.11.1.13877

Table 2.

Type of EGFR gene mutations

No Exon Type of sequence alteration Nucleotide alteration Amino acid alteration
1 18 Substitution 2174C→G 725(ACG-ATG) Thr-Met
2 18 Substitution 2073T→C 691(CCT-CCC) Pro-Pro
3 21 Substitution 2573T→G 858(CTG-CGG) Leu-Arg
4 18 Substitution 2091A→G 697(GAA-GAG) Glu-Glu
5 21 Substitution 2494C→T 832(CGC-TGC) Arg-Cys
21 Substitution 2604A→T 868(GAA-GAT) Glu-Asp
6 18 Substitution 2160C→A 720(TCC-TCA) Ser-Ser
21 Substitution 2556G→T 852(AAG-AAT) Thr-Met
7 18 Substitution 2173A→G 725(ACG-GCG) Thr-Ala
8 19 Deletion 2235–2249del GGA ATT AAG AGA AGC E746-A750 deletion
9 19 Deletion 2235–2249del GGA ATT AAG AGA AGC E746-A750 deletion
10 18 Substitution 2112G→A 704(TTG-TTA) Leu-Leu
11 18 Substitution 2108T→C 703(CTC-CCC) Leu-Pro
18 Substitution 2159C→T 720(TCC-TTC) Se-Phe
12 18 Substitution 2099A→G 700(AAC-AGC) Asn-Ser
13 21 Substitution 2506C→A 836(CGC-AGC) Arg-Ser
14 18 Substitution 2123A→G 708(AAG-AGG) Lys-Arg
15 18 Substitution 2165C→A 722(GCG-GTG) Ala-Val
16 18 Substitution 2159C→T 720(TCC-TTC) Ser-Phe
19 Substitution 2232C→A 744(ATC-ATT) Ile-Ile
17 18 Substitution 2161G→A 721(GGT-AGT) Gly-Ser
21 Substitution 2597A→G 866(GAG-GGG) Glu-Gly
18 18 Substitution 2108T→C 703(CTC-CCC) Leu-Pro
19 21 Substitution 2559C→T 853(ATC-ATT) Ile-Ile
20 18 Substitution 2122A→G 708(AAG-GAG) Lys-Glu
21 18 Substitution 2108T→C 703(CTC-CCC) Leu-Pro
22 21 Substitution 2472C→A 824(GGC-GGA) Gly-Gly
23 18 Substitution 2136C→T 712(TTC-TTT) Phe-Phe
24 21 Substitution 2481C→T 827(TAC-TAT) Tyr-Tyr